This innovative method has the potential to unlock new treatment options for chronic conditions driven by mitochondrial dysregulation.
HOUSTON, March 04, 2025 (GLOBE NEWSWIRE) -- FibroBiologics, Inc. (Nasdaq: FBLG) ("FibroBiologics”) , a clinical-stage biotechnology company with 160+ patents issued and pending with a focus on the development of therapeutics and potential cures for chronic diseases using fibroblasts and fibroblast-derived materials, announced the filing of a patent application with the United States Patent and Trademark Office covering methods employing fibroblasts to improve mitochondrial performance in cells.
Mitochondria are critical organelles responsible for cellular energy production via oxidative phosphorylation. Mitochondrial dysregulation is implicated in aging, and a wide range of diseases including autoimmune, neurodegenerative, metabolic, and muscular diseases. Fibroblasts, primary cells for the secretion and maintenance of connective tissue, secrete bioactive molecules such as growth factors, cytokines, and extracellular vesicles that influence cellular microenvironments.
Modulating mitochondrial function using local or systemic fibroblast administration, represents a novel method to address mitochondrial dysregulation—an area of increasing focus in medical research. This novel approach has the potential to unlock new treatment options for conditions driven by mitochondrial dysfunction that contribute to the pathology of many chronic diseases.
"Using fibroblasts to improve the microenvironment of the cells by modulating mitochondrial activity has the potential of fundamentally altering how we treat chronic diseases, and positively impact human longevity," said Pete O'Heeron, Founder & Chief Executive Officer of FibroBiologics.
“There has been growing interest in the research community around leveraging mitochondria-focused therapies to address chronic diseases,” said Hamid Khoja, Chief Scientific Officer of FibroBiologics. “Our approach takes advantage of fibroblasts’ natural ability to modulate mitochondrial function, potentially unlocking new therapeutic strategies for the treatment of multiple chronic diseases.”
About FibroBiologics
Based in Houston, FibroBiologics is a clinical-stage biotechnology company developing a pipeline of treatments and potential cures for chronic diseases using fibroblast cells and fibroblast-derived materials. FibroBiologics holds 160+ US and internationally issued patents/patents pending across various clinical pathways, including disc degeneration, orthopedics, multiple sclerosis, psoriasis, wound healing, reversing organ involution, and cancer. FibroBiologics represents the next generation of medical advancement in cell therapy.